Diagnosis and treatment of bilio-pancreatic disorders in pediatric patients. Experience from a tertiary care center

Authors

Keywords:

coledocolitiasis, CPRE, Colangiopancreatografía retrograda endoscópica, esfinterotomía, pediatría

Abstract

Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is a useful endoscopic procedure for the diagnosis and treatment of biliary tract and pancreatic conditions in children.

Objective: To describe the results of endoscopic retrograde cholangiopancreatography in pediatric patients with biliopancreatic disorders.

Methods: An observational, descriptive, cross-sectional study was carried out at the Hepato-Biliary Surgery and Liver Transplant Service of the ?William Soler? Pediatric Teaching Hospital from February 4, 2012 to December 20, 2019. Endoscopic retrograde cholangiopancreatography studies were reviewed and clinical data, indications, diagnoses and complications were recorded.

Results: Fifty-three children were included with 14 (5-18) years of median (range) age, 33 (62%) were female. Of seventy-eight cholangiopancreatographies performed, 18 (23%) were diagnostic and 60 (77%) therapeutic.? The main indication of the study was abdominal pain with cholestasis in 37 (47%) patients.Post-surgical stenosis of the biliary tract was the main diagnosis in 23 (29%), followed by normal studies in18 (23%). Biliary sphincterotomy was performed in 50 (83.3%) patients and bile duct prosthesis placement in 17 (28.3%) cases. A 98.7% cannulation rate was obtained. Complications occurred in three cases (5%), two patients(3.3%) presented post-ERCP mild pancreatitisand one (1.7%). Cholangitis. No deaths were reported.

Conclusions: The results prove the success achieved in specialized centers for endoscopic diagnosis and therapy of biliopancreatic disorders in pediatric patients with minimal complications.

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References

Asenov Y, Akın M, Cantez S, Gün Soysal F, Tekant Y. Endoscopic retrograde cholangiopancreatography in children: Retrospective series with a long-term follow-up and literature review. Turk J Gastroenterol. 2019 Feb;30(2):192-197. doi: 10.5152/tjg.2018.18165. PMID: 30459128; PMCID: PMC6408168. https://doi.org/10.5152/tjg.2018.18165

Waye JD. Endoscopic retrograde cholangiopancreatography in the infant. Am J Gastroenterol. 1976 May;65(5):461-3. https://pubmed.ncbi.nlm.nih.gov/949055/

Nabi Z and Reddy DN.Advanced Therapeutic Gastrointestinal Endoscopy in Children. Today and Tomorrow. Clin Endosc 2018; 51: 142-149. https://doi.org/10.5946/ce.2017.102

Torun S, Parlak E, Yıldız H, et al. Assessment of the endoscopic retrograde cholangiopancreatography grading system: A prospective study from a tertiary care center. Turk J Gastroenterol 2016; 27: 187-91. https://doi.org/10.5152/tjg.2015.150366

Durakbasa CU, Balik E, Yamaner S, et al. Diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children and adolescents: experience in a single institution. Eur J Pediatr Surg 2008; 18: 241-4. https://doi.org/10.1055/s-2008-1038497

Taj MA, Leghari A, Qureshi S, Ghazanfar S, Niaz SK, Quraishy MS. Endoscopic retrograde cholangiopancreatography: a therapeutic modality in children and adolescents. J Pak Med Assoc. 2012 Feb;62(2):98-101. PMID: 22755366. https://pubmed.ncbi.nlm.nih.gov/22755366/

Pant C, Sferra TJ, Barth BA, Deshpande A, Minocha A, Qureshi WA, Olyaee M, Anderson MP. Trends in endoscopic retrograde cholangiopancreatography in children within the United States, 2000-2009. J Pediatr Gastroenterol Nutr. 2014 Jul;59(1):57-60. doi: 10.1097/MPG.0000000000000333. PMID: 24509307. https://pubmed.ncbi.nlm.nih.gov/24509307/

Halvorson L, Halsey K, Darwin P, Goldberg E. The safety and efficacy of therapeutic ERCP in the pediatric population performed by adult gastroenterologists. Dig Dis Sci. 2013 Dec;58(12):3611-9. doi: 10.1007/s10620-013-2857-9. Epub 2013 Sep 12. PMID: 24026405. https://pubmed.ncbi.nlm.nih.gov/24026405/

Brizuela Quintanilla RA, Ruiz Torres JF, Ramos Contreras JY, García-Menocal Hernández JL, Alonso Contino N, Becil Poyato S, et al.Tratamiento endoscópico de afecciones biliopancreáticas en niños. Análisis de 31 pacientes. Endoscopia. 2016;28(1):16-20. http://www.sciencedirect.com/science/article/pii/S0188989316300045

Brizuela Quintanilla RA, Ramos Contreras JY, Ruiz Torres JF, Becil Poyato S, García-Menocal Hernández J, Alonso Contino N, Villamil Martínez R. Endoscopic Treatment of Biliopancreatic Affections in Children. Experience in Cuba”. Acta Scientific Gastroenterology 1.1 (2018): 05-08. Disponible en: https://actascientific.com/ASGIS/pdf/ASGIS-01-0003.pdf

Advances in endoscopy: current developments in diagnostic and therapeutic endoscopy. OMED Guidelines for Credentialing and Quality Assurance in Endoscopy. Gastroenterol Hepatol (N Y). 2010 Apr;6(4):216-7. PMID: 20567571; PMCID: PMC2886480. https://pubmed.ncbi.nlm.nih.gov/20567571/

NIH State-of-the-Science Statement on Endoscopic Retrograde Cholangiopancreatography (ERCP) for Diagnosis and Therapy. In: NIH Consensus and State-of-the-Science Statements. 2002; 19: 1-23. Disponible en: http://www.nlm.nih.gov/pubs/resources.html#2002.

Liu W, Wang Q, Zeng H, Mou Y, Yi H, Wu C, Hu B, Tang C. [Analysis of the role of endoscopic retrograde cholangiopancreatography in children with pancreaticobiliary diseases]. Zhonghua Er Ke Za Zhi. 2014 May;52(5):328-32. Chinese. PMID: 24969928. https://pubmed.ncbi.nlm.nih.gov/24969928/

Cheng CL, Fogel EL, Sherman S, McHenry L, Watkins JL, Croffie JM, Gupta SK, Fitzgerald JF, Lazzell-Pannell L, Schmidt S, Lehman GA. Diagnostic and therapeutic endoscopic retrograde cholangiopancreatography in children: a large series report. J Pediatr Gastroenterol Nutr. 2005 Oct;41(4):445-53. doi: 10.1097/01.mpg.0000177311.81071.13. PMID: 16205513. https://pubmed.ncbi.nlm.nih.gov/16205513/

Rocca R, Castellino F, Daperno M, Masoero G, Sostegni R, Ercole E, Lavagna A, Barbera C, Canavese F, Pera A. Therapeutic ERCP in paediatric patients. Dig Liver Dis. 2005 May;37(5):357-62. doi: 10.1016/j.dld.2004.09.030. PMID: 15843086. https://pubmed.ncbi.nlm.nih.gov/15843086/

Pfau PR, Chelimsky GG, Kinnard MF, Sivak MV Jr, Wong RC, Isenberg GA, Gurumurthy P, Chak A. Endoscopic retrograde cholangiopancreatography in children and adolescents. J Pediatr Gastroenterol Nutr. 2002 Nov;35(5):619-23. doi: 10.1097/00005176-200211000-00006. PMID: 12454575. https://pubmed.ncbi.nlm.nih.gov/12454575/

Katz LH, Benjaminov O, Belinki A, Geler A, Braun M, Knizhnik M, et al .Magnetic resonance cholangiopancreatography for the accurate diagnosis of biliary complications after liver transplantation:comparison with endoscopic retrograde cholangiography and percutaneous transhepatic cholangiography – long-term follow-up. Clin Transplant 2010: 24: E163–E169 DOI: 10.1111/j.1399-0012.2010.01300.x

Saito T, Terui K, Mitsunaga T, Nakata M, Kuriyama Y, Higashimoto Y, Kouchi K, Onuma N, Takahashi H, Yoshida H. Role of pediatric endoscopic retrograde cholangiopancreatography in an era stressing less-invasive imaging modalities. J Pediatr Gastroenterol Nutr. 2014 Aug;59(2):204-9. doi: 10.1097/MPG.0000000000000399. PMID: 24762457. https://pubmed.ncbi.nlm.nih.gov/24762457/

. Usatin D, Fernandes M, Allen IE, et al. Complications of Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients: A Systematic Literature Review and Meta-Analysis. J Pediatr 2016; 179: 160-5. https://doi.org/10.1016/j.jpeds.2016.08.046

Giefer MJ, Kozarek RA. Technical outcomes and complications of pediatric ERCP. Surg Endosc 2015; 12: 3543-50. https://doi.org/10.1007/s00464-015-4105-1

Issa H, Al-Haddad A, Al-Salem AH. Diagnostic and therapeutic ERCP in the pediatric age group. Pediatr Surg Int 2007; 23: 111-6. https://doi.org/10.1007/s00383-006-1832-3

Durakbasa CU, Balik E, Yamaner S, et al. Diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children and adolescents: experience in a single institution. Eur J Pediatr Surg 2008; 18: 241-4. https://doi.org/10.1055/s-2008-1038497

Paris C1, Bejjani J, Beaunoyer M, et al. Endoscopic retrograde cholangiopancreatography is useful and safe in children. J Pediatr Surg 2010; 45: 938-42. https://doi.org/10.1016/j.jpedsurg.2010.02.009

Otto AK, Neal MD, Slivka AN, et al. An appraisal of endoscopic retrograde cholangiopancreatography (ERCP) for pancreaticobiliary disease in children: our institutional experience in 231 cases. Surg Endosc 2011; 25: 2536-40. https://doi.org/10.1007/s00464-011-1582-8

Published

2021-02-12

How to Cite

1.
Ramos Contreras JY, Brizuela Quintanilla RA, Villamil Martíinez R, Ortega Dugrot Y. Diagnosis and treatment of bilio-pancreatic disorders in pediatric patients. Experience from a tertiary care center. Arch.cuba.gastroenterol. [Internet]. 2021 Feb. 12 [cited 2025 Apr. 4];2(3). Available from: https://revgastro.sld.cu/index.php/gast/article/view/92

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ARTÍCULOS ORIGINALES