Effect of sustained virological response on quality of life in chronic hepatitis C patient
Keywords:
Quality of Life; , Health-Related Quality of Life, Hepatitis C, Chronic Hepatitis C virus, Patient Reported Outcome Measures, Antiviral AgentsAbstract
Introduction: Chronic hepatitis C virus infection is associated with a detriment in quality of life. Scientific evidence of the impact of direct-acting antivirals on health-related quality of life comes mostly from clinical trials. The aim of the present study is to identify the effect of sustained virological response on health-related quality of life in patients with chronic HCV infection in the real-life setting.
Methods: a prospective longitudinal descriptive study was conducted in chronic hepatitis C infected patients treated with DAAs between January 2019 and December 2021 at the Institute of Gastroenterology. The results of the hepatitis C specific chronic liver disease questionnaire, functional assessment for the treatment of chronic disease-fatigue and the work productivity and activity impairment questionnaire - specific health problem were recorded, as well as clinical-demographic parameters at baseline and 12 weeks after the end of treatment.
Results: 56 patients were evaluated with mean age 57.4 +/- 8.3 years, 20 (35.7%) men. Total scores (before versus after treatment) of hepatitis C specific chronic liver disease questionnaire: (4.67 +/- 1.12 vs 5.21 +/- 1.18; p=0.0062), functional assessment for the treatment of chronic disease-fatigue:(115.8 +/- 22.5 vs 124.2 +/- 19.7; p=0.0217) and work productivity and activity impairment questionnaire: (0.420 +/- 0.302 vs 0.323 +/- 0.290; p=0.0138) improved at the end of treatment.
Conclusions: New direct-acting antivirals, in patients with hepatitis C, achieve high response rates, and improve early and overall health-related quality of life.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Archivos Cubanos de Gastroenterología
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
La revista reconoce a las personas que firman como autores siempre y cuando estos cumplan con los criterios establecidos universalmente para los autores de los art?culos cient?ficos. Regularmente se solicitar? a los autores de art?culos originales, env?en la declaraci?n de autor?a firmada por cada uno de ellos y donde se explique su rol dentro de la investigaci?n. El comit? editorial se reserva el derecho de aceptar determinados autores en relaci?n con el rol declarado y la envergadura de la investigaci?n.
Esta revista protege los Derechos de autor desde el mismo momento en que se realiza el env?o. Sin embargo, cede parte de los derechos patrimoniales de autor al exhibir una licencia Creative Commons 4.0 (cc-by-nc), que permite el uso de la obra para compartir (copiar y redistribuir el material en cualquier medio o formato) y adaptar (remezclar, transformar y construir a partir del material) siempre y cuando se haga menci?n exclusiva a la publicaci?n en la revista como fuente primaria. ?Sin embargo, no podr? comercializar con ella.
?
